Both experimental hypothyroidism and hyperthyroidism increase cardiac irisin levels in rats
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چکیده
منابع مشابه
Both hypothyroidism and hyperthyroidism increase atrial fibrillation inducibility in rats.
BACKGROUND Evidence indicates that cardiac hypothyroidism may contribute to heart failure progression. It is also known that heart failure is associated with an increased risk of atrial fibrillation (AF). Although it is established that hyperthyroidism increases AF incidence, the effect of hypothyroidism on AF is unclear. This study investigated the effects of different thyroid hormone levels, ...
متن کاملBoth hypothyroidism and hyperthyroidism enhance low density lipoprotein oxidation.
Hypothyroidism is frequently associated with hypercholesterolemia and an increased risk for atherosclerosis, whereas hyperthyroidism is known to precipitate angina or myocardial infarction in patients with underlying coronary heart disease. We have shown previously that L-T4 functions as an antioxidant in vitro and inhibits low density lipoprotein (LDL) oxidation in a dose-dependent fashion. Th...
متن کاملirisin levels increase during experimentally induced acute myocardial infarction
BACKgROunD: Irisin is a hormone involved in energy metabolism. To date, however, there are scant data regarding irisin levels in infarcted tissues. OBjECTIVE: To evaluate changes in irisin levels in the cardiac tissue of rats during experimentally induced myocardial infarction (MI). METhODS: A total of 21 rats, comprising three groups of seven animals each (MI-1, MI-2 and a control group), were...
متن کاملBiochemistry of hyperthyroidism and hypothyroidism.
The thyroid hormones act directly on mitochondria, and thereby control the transformation of the energy derived from oxidations into a form utilizable by the cell. Through their direct actions on mitochondria, the hormones also control indirectly the rate of protein synthesis and thereby the amount of oxidative apparatus in the cell. A rationale for the effects of thyroid hormone excess or defi...
متن کاملThe Bone Marrow in Hyperthyroidism and Hypothyroidism
By ARNOLD R. AXELROD, M.D. AND LAWRENCE BERMAN, M.D. D URING THE PAST HALF CENTURY there has been an extensive accumulation of literature dealing with the relationship between the function of the thyroid gland and the status of the blood and bone marrow. Much of it is fragmentary and contradictory. We have attempted! to gather the available facts and augment these with original observations in ...
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ژورنال
عنوان ژورنال: Bratislava Medical Journal
سال: 2018
ISSN: 1336-0345
DOI: 10.4149/bll_2018_007